CUSAT IQAC Profile
https://iqac.cusat.ac.in/Web/profile_view/121/Dr.AJITHVENGELLUR

Dr. Vengellur received his BSc. in Agriculture from Kerala Agricultural University in 1997, his MSc. from GB Pant University of Agriculture and Technology in 2000, and earned his Ph.D. in Genetics from Michigan State University in 2007. He did his doctoral and postdoctoral training under Dr. John Lapres at the Department of Biochemistry and Molecular Biology at Michigan State University. At CUSAT he is also affiliated with the Centre for Advanced Materials (CAM) and Inter University Centre for Nanomaterials and Devices (IUCND).

His research interests include elucidation of molecular signaling pathways in development and disease, such as cancer, ischemia and neurodegenerative diseases; and effect of environmental contaminants such as metals, PCBs, and other toxicants on these pathways. He is also interested in the development of therapeutics and diagnostic tools for various medical health problems such as sepsis, cancer and neurodegenerative diseases

Publications

1. Hwang HJ, Lynn SG, Vengellur A, Saini Y, Grier EA, Ferguson-Miller SM, LaPres JJ. Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes. Biochemistry. 2015 Jun 23; 54(24):3739-48.

2. Tappenden, D.M., Lynn, S.G., Crawford, R.B., Lee, K., Vengellur, A., Kaminski, N.E., Thomas, R.S., and LaPres, J.J., 2011. The aryl hydrocarbon receptor interacts with ATP5a1, a subunit of the ATP synthase complex, and modulates mitochondrial function. Toxicol. Appl. Pharmacol. 254(3): 299-310.

3. Vengellur, A., Grier, E., and LaPres, J.J., 2011. The loss of HIF1a leads to increased susceptibility to cadmium chloride-induced toxicity in mouse embryonic fibroblasts. J. Toxicol. 2011; 2011:391074.

4. Vengellur, A., Phillips, J.M., Hogenesch, J., and LaPres, J.J., 2005. Gene expression profiling of the hypoxia signaling in human hepatocellular carcinoma cells. Physiol. Genomics. 11; 22(3):308-18.

5. Vengellur, A., and LaPres, J.J., 2004. The role of hypoxia inducible factor 1a in cobalt chloride induced cell death in mouse embryonic fibroblasts. Toxicol. Sci. 82, 638-46.

6. Vengellur, A., Woods, B.G., Ryan, H.E., Johnson, R.S., and LaPres, J.J., 2003. Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts. Gene Expr. 11(3-4):181-97.

For More Publications

https://www.ncbi.nlm.nih.gov/pubmed/?term=vengellur