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POORNIMA GOPI
POORNIMA GOPI
Ph. D Student
Study on Molecular Mechanisms of Na+/H+ Exchanger 1 regulation in Epstein Barr Virus Associated Cancer
Contact: poornimaprasanth25@gmail.com

Epstein–Barr virus (EBV) is associated with a diverse range of human neoplasms, such as malignant lymphoma, nasopharyngeal carcinoma, gastric cancer etc. Na+/H+ Exchanger 1 is an ubiquitously expressing secondary membrane transporter found to be involved in pH homeostasis, cell migration and differentiation of normal cells. Also NHE1 is likely to have constitutively expressed in a tumor microenvironment, dysregulating pH homeostasis and altering the survival, differentiation, and proliferation of cancer cells. Since there are no scientific report for the involvement of NHE1 in EBV induced cancers, this study has taken an approach to disclose the role and mechanism of NHE1 mediated ion transport in EBV driven cancer progression.

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